Anaphylaxis Prevention & Treatment


Patients who have previously experienced anaphylactic episodes should wear a Medic-Alert bracelet and be instructed regarding the importance of relating details of their specific drug reactions before taking medications. The medical history and medical record must include not only the allergic history but also a description of the associated symptoms. The physician must be aware […]

Pathogenesis of Anaphylaxis


Antigenic induction of IgE formation requires antigenic processing by dendrite cells or macrophages, T-cell help, and switching of B lymphocytes from IgG synthesis to IgE synthesis. Interleukin-4 and interleukin-13 are critical for the latter switch and function as T-cell helper factors for IgE formation. Subsequent combination of antigen with IgE bound to high-affinity receptors on […]

Anaphylaxis Differential Diagnosis


The diagnosis of systemic anaphylaxis may be obvious when a typical history of antecedent exposure to foreign antigenic material and a sequence of events consistent with the syndrome are present. Confirmation usually requires demonstration of IgE antibody to the substance by skin or radioallergosorbent testing. When a history of exposure is absent or when only […]

Anaphylaxis in Clinical Aspect


IgE-mediated anaphylaxic reactions can cause symptoms involving the cutaneous, respiratory, cardiovascular, gastrointestinal, and hematologic system. The onset and manifestations vary according to the route of administration, dose, release of and sensitivity to vasoactive substances, and differing sensitivities of the organs to these substances. These parameters can vary from person to person, and individuals tend to […]

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